What is LabNaturals Soft Gel Technology?
May 5, 2020
Folium's soft gels are made by solubilizing hemp oil by converting it into an oil-in-water type nanoemulsion. The unique advantage of this formulation is the enhanced surface area of cannabinoids resulting in higher bioavailability (4-6 times higher for CBD compared with oil form), consistency of the biological effects, and independence from fed- vs. fasting effects. The soft gels can be taken with or without food, without much impact on its efficacy.
This technology platform is depicted by the schematic below where the customization of the formulation can lead to addition of synergistic botanical or pharmaceutical ingredients. For example, cannabidiol and curcumin can be combined to address inflammation through independent pathways, making the resulting product a lot more effective, not to mention curcumin is up to 200 times more bioavailable in a water-soluble nanoemulsion form than its oil form.
Another example of synergistic ingredients in a soft gel is CBD combined with melatonin, where sleep is induced due to melatonin and sleep quality is preserved through CBD.
Additional soft gel formulations are possible to differentiate a product and increase its effectiveness.
How is Folium's water-soluble technology superior to other water-soluble technology, liposomal or micelle-based, in the market?
Folium's nanoemulsions are a finely-engineered formula that uses optimized composition and a unique process to manufacture. The average size of the hemp oil droplet is 25 nanometers, compared with 100-5000 nanometers that is usually obtained by using the industry standard liposomal delivery method. The small size of the Folium nanoemulsion leads to a much larger surface area of the hemp oil droplets in soft gels, leading to much higher absorption in blood. Hemp oil nanoemulsions can also be used in a number of commercial areas, including the cosmetic, pharmaceutical and food industries. Their lipophilic (oily) interior (i.e. ability to dissolve in fats, oils, lipids, and non-polar solvents) makes them a much better option for transporting lipophilic compounds compared to liposomes, and as such they more efficiently enable the skin penetration of active ingredients. Furthermore, due to their transparent properties and extremely small droplet size, nanoemulsions do not lead to phase-separation (oil separating from water), and thus enable the formulation of sprayable products.