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"Wonderful ordering from Lab Naturals! Dr. Merenstein has been promptly responsive to my questions. DHEA suppositories have been very helpful. They are easy to use and work quite well. Thank you!"
-B. H.
"Our physician thinks highly of your DHEA suppositories, as several of his patients have had positive results.”
- A.
DHEA Suppositories- A Recent Study Effect of intravaginal dehydroepiandrosterone (prasterone) on libido and sexual dysfunction in postmenopausal women.
According to the study, since the ovules (suppositories) used yielded different mg DHEA per supplement…
3 SYMPTOMS were reported:
64% vaginal pain at sexual activity
28% vaginal dryness
8% irritation and itching
Results after 12 weeks of using DHEA suppositories:
Score of the sexual domain of the MENQOL
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54% improvement using 0.25% DHEA
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43% improvement using 0.5% DHEA
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53% improvement using 1% DHEA
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Placebo- 32% improvement
Avoiding intimacy scores
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0.25% DHEA decreased scores by 46%
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0.5%- decreased by 53%
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1.0%- decreased by 51%
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Placebo- decreased by 26%
Vaginal Dryness
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0.25% DHEA resulted in 58% decrease in severity score
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0.5%- 53% decrease in severity
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1.0%- 57% decreases in severity
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Placebo- decreased by 28%
Sexual desire improvement
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0.25% DHEA showed 55% improvement
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0.5%- 32% improvement
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1.0%- improved by 49%
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Placebo- 23% improvement
Arousal - lubrication
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0.25% DHEA- lubrication improved by 169%
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0.5%- improved by 162%
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1.0%- 139% improvement
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Placebo- 49% improvement
Orgasm (increases from baseline)
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0.25% DHEA- patients reported 65% increase from baseline
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0.5% DHEA- 56% increase
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1.0%- 75% increase
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Placebo- 31% increase from baseline
Conclusions:
The new knowledge gained about intrcrinology in women clearly indicated that the appearance of symptoms of vaginal atrophy in postmenopausal women is due to a lack of DHEA and/or insufficient transformation of this precursor into active androgens and/or estrogens in the vagina. Most interestingly, the present data show that in addition to very rapidly and efficiently correcting the symptoms and signs of vaginal atrophy, the local application of DHEA in the vagina has a marked influence on all aspects of sexual function, this indicating the role of an androgenic component of DHEA transformation on vaginal health, which permits improvement in desire, arousal, orgasm, and pleasure.
The present beneficial effects of intravaginal DHEA on sexual dysfunction in women, including orgasm, can be compared to the success of oral therapy for erectile dysfunction in men. A marked difference, however, between the treatment of erectile dysfunction in men and the present treatment of sexual dysfunction in women is that local treatment with DHEA achieves its beneficial effects without significant systemic exposure to a drug, thus avoiding potential systemic risks.”
*DHEA vaginal suppositories (ovules) 2.75mg each
Directions for use: Insert 1 suppository into vagina every night for 12 weeks, then 2-3 times per week.
References:
Labrie F, Archer D, Bouchard C, et. al. Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women. Menopause: The Journal of The North American Menopause Society. 2009:16(5);923-31.
*Note change in dose recommendation verses dose used in study.
*Storage and Shipping Information for Compounded Suppositories:
Typically, all compounded suppositories are stored under refrigeration. This is to ensure they are kept in an unvarying temperature environment and, most often, not for drug stability. We also recommend leaving your current dose outside of the refrigerator for at least 15 minutes prior to insertion, this allows for easier removal from the mold without breaking or cracking the suppository.
When shipping our suppositories, the manner in which they are shipped depends greatly on several factors, including: seasonal temperature, distance traveled and drug stability. Our ice packs are manufactured to distribute hot or cold in accordance with product and surrounding temperatures. Ice packs may reach you frozen or unfrozen; this is because they are used to stabilize the temperature of the package during the shipping. Receiving an unfrozen ice pack does not mean that your product has been compromised.
Murray Avenue Apothecary is not responsible for the product once it leaves the Apothecary once you choose a shipping and handling option.
We want to assure you that the pharmacists and technicians at Murray Avenue Apothecary take every precaution to get your products to you, so that you receive the highest quality item. If you have any questions, please don’t hesitate to call us at 412-586-4678 or email at susan@maapgh.com.
